The story of ingredients like BMPEA has been seen over and over again in the world of supplements. Just like its dangerous predecessors (such as ephedra and DMAA), BMPEA was created to act as a stand-in for wild stimulants like amphetamines, which (despite their dangers) are known for their ability to grant massive boosts of energy alongside a potential weight loss effect. Unfortunately for the unscrupulous manufacturers and sellers of these substances, the obvious risks and drawbacks of untested stimulants always draws the attention of regulators like the FDA and the EU, who waste little time in banning them and removing them from sale. Supplement manufacturers that come up with a new chemical Frankenstein’s monster that does roughly the same thing, and the process of regulatory whack-a-mole begins anew!

Below we take an in-depth look into Thyroxagen, to see the various health risks this now-banned product threatened its customers with.

Thyroxagen Pros

  • In theory, it could work well as a weight loss aid

Thyroxagen Cons

  • No longer available to buy, as key ingredients have been effectively banned
  • Likely to cause dangerous and debilitating side effects
  • Important ingredient quantity information is missing
  • Manufacturer has no money back guarantee or returns policy
Watchdog Rejected



What You Need To Know About Thyroxagen

Thyroxagen is a weight loss product that contains the now-banned ingredient BMPEA. It was first placed on sale in 2014, and has since seemingly been discontinued following the FDA’s decision to outlaw the use of BMPEA in the unregulated supplement market. Along with BMPEA (a cousin of amphetamines like speed), this product relied on a host of other stimulant ingredients like synephrine, caffeine, and Yohimbe, all of which would have combined to create a capsule rife with side effects!

What Are The Side Effects Of Thyroxagen?

This product has been removed from the market for good reasons – it likely causes serious side effects and should be avoided.

Although the safety profile of BMPEA is very poorly understood, its chemical structure makes it likely to pose the same risks as other banned ingredients like DMAA and ephedra. These ingredients raise the blood pressure, and have been linked to heart attacks, strokes, and even deaths. Another ingredient used in this product (synephrine) poses many of the same risks, all of which are made worse when combined with caffeine.

On a good day, excess caffeine can cause sleeplessness, jitters, irritability, shakes, and excess urination. The various stimulants that have been combined in this product likely produce exaggerated versions of these effects, plus the mood swings and anger associated with yohimbine.

We wish this was a complete list, but the number of potential side effects customers may encounter whilst using Thyroxagen are too extensive to list here. Please check our Side Effects tab for the full depressing list!

How Much Does Thyroxagen Cost?

Thyroxagen is no longer available to buy on the Internet, but when it was sold it used to retail for around $29.99 for a 2-month supply (with free shipping).

Our Verdict On Thyroxagen

We weren’t present at the meeting that decided to pull Thyroxagen from store shelves, but we’re sure we know why that decision was made. Thyroxagen is a frankly dangerous product, and one that is now effectively banned by the US Food and Drug Administration (FDA).

Even if it had not been formally banned, this product should always have been avoided at all costs. It uses an almost-vindictive combination of various risky stimulants, which could certainly have led to several side effects and health risks. If you think the idea of taking narcotics like speed or MDMA is a reckless way of losing weight and gaining energy, then you surely see the dangers in relying on products like these – they are effectively formulated in the same way and for the same purpose.

Thyroxagen is of course not available to buy online anymore after the BMPEA ban, but if you happen to spot any left over at home or in the gym, avoid it like the plague. Your health isn’t worth risking for the mild weight loss benefits you could experience!

Overall, we do not recommend Thyroxagen to our readers.

Thyroxagen Review

Thyroxagen is a fat-burning weight loss supplement, that is aimed mainly at the bodybuilding and male athlete market. This product appeared to go up for sale in around 2014, but has since been removed from sale from all websites online (and is often listed as discontinued). However, the sales page is still up on the manufacturer’s website, which perhaps suggests that the product may only be temporarily side-lined and could make a comeback one day.

Thyroxagen Facts

  • Manufactured by Alpha Pro Nutrition
  • Contains 120 capsules per bottle
  • Temporarily discontinued fat-burning weight loss supplement

Thyroxagen is manufactured by Alpha Pro Nutrition, a relatively new supplement company from Los Angeles, USA. Despite their tiny size and relative “unknown” status in the world of supplements, Alpha Pro Nutrition appear to be ambitious and confident. Their seemingly high-budget adverts on YouTube are notable for their dramatic “movie advert” voiceovers and attractive bodybuilder promoters, which makes for an interesting (albeit cheesy) watch. Tragically, Alpha Pro Nutrition’s adverts and products continue to attract very little attention, with most social media posts and videos attracting well under 1000 views per post. The company can be contacted via email at [email protected] (international customers should use the [email protected] email) or through their social media pages.

How to Take Thyroxagen

The directions for use are as follows:

Assess tolerance by taking one capsule in the morning. May add another capsule in the early aftenoon, or two in the morning. Should not exceed 2 capsules in one day.

Thyroxagen Concerns:

  • Product is not currently available to buy online
  • Ingredient quantities not listed
  • Product carries a strong likelihood of causing dangerous side effects

What Does Thyroxagen Claim To Do?

On its official product page, Thyroxagen is said to act a fat-burning weight loss pill, and one that is able to target “problem areas” such as the stomach, upper thighs, and butt. Thyroxagen’s use of the ingredient yohimbine is said to induce lipolysis (the process of stored fat being burnt up and used as energy). Other ingredients are said to increase focus, alertness, and energy, with some stimulant effects reportedly boosting the body’s metabolism. Finally, the use of ingredients like N-Methyl-Beta-Methylphenylethylamine HCL and R-beta Methylphenylehtylamine is said to boost the levels of dopamine in the brain; this apparently not only makes customers feel better throughout the day, but also gives a feeling of “fullness” that reduces cravings and the subsequent problem of overeating.

The full list of benefits provided on the Alpha Pro Nutrition website are as follows:

  • Burns core fat for 6 hours
  • Shuts down fat storage
  • Increases mental focus
  • Contains new Alpha-Yohimbine
  • Fast acting / time released capsules

Does Thyroxagen Work?

Thyroxagen is highly reliant on stimulants and substances that are designed to imitate amphetamines, meaning that it will undoubtedly cause a huge rush of energy which will likely be accompanied by a feeling of wellbeing and positivity. The effect is likely not dissimilar to that which would be experienced by taking speed or ecstasy.

Habitual users of narcotics like these will tell you that weight loss and a loss of appetite is to be expected, and we believe that Thyroxagen could work well as a fat burner or general weight loss aid given its ingredient profile. The real question is whether it is worth threatening your health to such a dangerous extent in order to achieve this effect!

What Are The Ingredients of Thyroxagen?

The ingredients found in Thyroxagen are listed below. Unfortunately, the manufacturer does not provide exact ingredient quantities for each ingredient, which can make it difficult or impossible for customers to estimate how effective the overall mix is. The ingredient quantities that are listed are correct for 2 capsules (1 serving) of Thyroxagen.

Thyroxagen Lipolytic Activator 224mg

  • Caffeine Anhydrous: Numerous studies have shown that caffeine boosts energy levels and alertness, as well as mildly boosting the metabolism, causing a small increase in the number of calories used by the body. The effects shown in studies are small, and some studies are inconclusive. Caffeine is known to slightly increase athletic performance and mental performance. Source
  • Toothed Clubmoss (Huperzia serrata) (leaves) [std. to 1% huperizine A]: Huperzine-A is found in Huperzia serrata, and is thought to be a cognitive enhancer. Previous studies have found it to be effective as a memory enhancer for adults suffering with Alzheimer’s or dementia. Because of the relatively long half-life of this compound, its use should be cycled, with breaks in usage every few weeks. Source
  • Yerba Mate Extract (lex paraguariensis) (leaves): A plant that is typically brewed as a tea, yerba mate is a natural source of caffeine, and has been the subject of several studies on weight loss. In a 2001 study of 47 healthy overweight adults, researchers found that taking an herbal preparation of yerba mate, guarana, and damiana three times daily for 45 days induced weight loss. It is not clear whether the individual ingredients from this preparation have the same weight loss potential on their own, or how much of each ingredient is required to replicate the results of the study. See our article on Yerba mate for more information. Source
  • Barley (Hordeum vulgare) (bud) [std. to hordenine HCI]: Hordenine is a known compound in Bitter Orange, and is thought to act as a stimulant to increase fat burning. Source

Alpha Pro Synephrine Appetite-Suppress 13mg

  • Synephrine HCI: A review of numerous studies concluded that use of synephrine resulted in an increase to the participants resting metabolic rate and energy expenditure, and moderate weight loss was seen in studies lasting over 6 weeks. However, there are some concerns about its safety being under-researched and the numerous side effects that have been associated with it. Source

Dopamine Booster 92mg

  • R-beta-Methylphenylethylamine
  • N-Methyl-beta-Phenylethylamine: These two complex names actually refer to the same basic substance: BMPEA. BMPEA is in the same chemical family as amphetamines and hallucinogens like mescaline, and is thought to raise blood pressure and heart rate. As it has never been tested on humans for safety, BMPEA is regarded by many as dangerous (extremely similar substances have been linked with heart attacks, strokes and deaths). As of November 2017, this ingredient has effectively been banned as a supplement ingredient by the FDA. Source; Source

Thyroxagen Alpha-Trio 6mg

  • Yohimbe (Coryanthe Yohimbe) (bark) [std. to yohimbine HCI]
  • Yohimbe (Coryanthe Yohimbe) (bark) [std. to 11-hydroxy yohimbine]
  • Yohimbe (Coryanthe Yohimbe) (bark) [std. to alpha yohimbine HCI]: Some studies have noticed increased blood concentrations of free fatty acids in participants who use yohimbe extract, suggesting increased rates of lipolysis. However, the Natural Medicines Comprehensive Database has stated that there is insufficient evidence to claim it aids in weight loss. Source

Does Thyroxagen Have Any Side Effects?

Thyroxagen appears to have been taken off of the market for a reason; it contains a number of ingredients that could cause highly serious side effects, up to and including death. We strongly recommend avoiding products like these.

The main problematic ingredient found in this product is one that has since been banned by the FDA: BMPEA. This cousin of amphetamines like MDMA and speed has never been tested on humans, and so its safety profile is unknown. However, very similar substances that have also been banned by the FDA (such as ephedra and DMAA) were linked to a spate of heart attacks, strokes and deaths before they were removed from the market. Specialists charged with studying phenylethylamines like BMPEA believe it has the same potential for harm, and their recommendations have surely lead to its removal from supplements like Thyroxagen.

Side effects associated with the use of another stimulant used in this product, Synephrine, include increased heart rate and increased blood pressure, heart palpitations, fainting, and even heart attacks and strokes in healthy patients. The effects of synephrine are enhanced when combined with caffeine.

Consuming large quantities of caffeine can lead to headaches, increased heart rate, increased blood pressure, heart palpitations, increased urination, dehydration, jitteriness, dizziness, and insomnia.

Huperzine A is known for its side effects, especially when taken continuously for 3 months or more. It has been known to cause digestive issues, stomach issues, blurred vision, loss of appetite, sweating, cramping, high blood pressure, and other issues.

Yohimbe can cause a wide range of side effects, including stomach upset, excitation, tremor, sleep problems, anxiety or agitation, high blood pressure, a racing heartbeat, dizziness, stomach problems, drooling, sinus pain, irritability, headache, frequent urination, bloating, rash, nausea, and vomiting. High doses can cause more severe effects.

Not suitable for pregnant or breastfeeding women. Not suitable for anyone under the age of 18. If you are taking any medications or are unsure about the suitability of this supplement for you, consult your doctor before purchase. Not suitable for anyone with any cardiac related health issues, including but not limited to high blood pressure. Not suitable for anyone with pre-existing anxiety issues. Not suitable for anyone with bipolar disorder, as yohimbe could trigger manic psychosis or suicidal episodes. Not suitable for anyone taking any neurological medications. BMPEA is an amphetamine, and is not safe to take, even if you are generally healthy. Do not take if you have a history of addiction. Not suitable for anyone who is taking MAO inhibitors, or who has taken them in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine. Not suitable for anyone with an overactive thyroid.

Call your doctor right away if you have: signs of heart problems – chest pain, feeling light-headed or short of breath; signs of psychosis – paranoia, aggression, new behaviour problems, seeing or hearing things that are not real, and signs of circulation problems – unexplained wounds on your fingers or toes.

Are There Any Customer Reviews For Thyroxagen?

Thyroxagen has been removed from sale across the web, and so it remains hard/impossible to find any former customers who remember trying it. If you have ever taken Thyroxagen before it was discontinued, we would love to hear more about your experiences – please consider leaving a comment below!

Does Thyroxagen Offer a Money-Back Guarantee?

On the official Alpha Pro Nutrition website, no mention is made of a money back guarantee or a returns policy of any kind.

Where Can I Buy Thyroxagen?

Thyroxagen is no longer available to buy, although it was once listed for sale on a number of retailers (including DPS Nutrition,, and the official Alpha Pro Nutrition website). It has since been listed as discontinued on all of these websites, except for the manufacturer’s website, which could suggest that it may make a comeback in the future (hopefully after being reformulated).

For those interested, a 120-capsule (2-month) supply of Thyroxagen used to sell for $29.99 on the official Alpha Pro Nutrition website (and came with free shipping).

Summary: Thyroxagen


1.8 out of 5
Thyroxagen Rating

The Muscle Watchdog does not recommend Thyroxagen.

  • Effectiveness
  • Safety
  • Price / Guarantee

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Disclaimer: Our reviews and investigations are based on extensive research from the information publicly available to us and consumers at the time of first publishing the post. Information is based on our personal opinion and whilst we endeavour to ensure information is up-to-date, manufacturers do from time to time change their products and future research may disagree with our findings. If you feel any of the information is inaccurate, please contact us and we will review the information provided.

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