PEScience Prolific

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PEScience Prolific is a pre-workout supplement, that contains a number of popular ingredients to help boost muscle performance. Its regular use is supposed to improve blood flow and reduce mental fatigue. Some of its ingredient may also help improve endurance and mind-muscle connection. It also claims to help you increase muscle mass, while reducing overall body fat percentage.

PEScience Prolific is designed to improve exercise performance by increasing blood flow and endurance. It also improves mental focus and makes it easier to handle strenuous workout sessions. The question is, is it better than other pre-workout supplements currently available in the market? Can it really help you gain muscle quickly? Here is our review to help you decide.

PEScience Prolific Pros

  • Natural ingredients
  • Two forms of caffeine

PEScience Prolific Cons

  • Under-dosed ingredients
  • Does nothing to increase energy
  • Does nothing to improve mind-muscle connection
  • Causes no change in focus or concentration
  • May cause several side effects
  • Costs more than other similar pre-workout supplements
Watchdog Rejected

PEScience Prolific

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What You Need To Know About PEScience Prolific

PEScience Prolific is a pre-workout supplement, that uses a combination of ingredients to boost endurance and performance in the gym. Some of its ingredients boost performance, while others are supposed to help you get a better pump. Its formula also contains cognitive and energizing components. Interestingly, it also works to improve mind-muscle connection, which helps you get the best out of your workouts. You experience a power contraction of muscles in each rep, which is supposed to help you have a better pump and improved gains. Unfortunately, there is not enough scientific evidence to support the formula used in PEScience Prolific. Many of its ingredients also seem under-dosed, which is the reason why we believe that it fails to fulfill the promises it makes.

What Are The Side Effects Of PEScience Prolific?

PEScience Prolific contains several ingredients, including stimulants, so it is natural to feel some side effects when you take it on a daily basis. You are likely to develop gastrointestinal side effects in the beginning, but some people may also complain about increased heart rate, high blood pressure, and insomnia. Refer to our “Side Effects” section to learn more.

How Much Does PEScience Prolific Cost?

You have to pay $42.75 to get a container of PEScience Prolific. Each container has 20 servings.

Our Verdict On PEScience Prolific

PEScience Prolific claims to power up your workouts, but the truth is that most of its ingredients fail to produce any result. L-citrulline may help improve endurance a little, but you may have to take larger doses to see results. You can get enough taurine from dietary sources, so you do not always need to supplement with it. Caffeine may improve concentration a little, but do not expect much in terms of muscle gain. Citicoline may improve brain health to a certain extent, but that is only when you take larger doses. Moreover, it does not make sense to pay a high price for a supplement with ineffective and under-dosed ingredients.

Overall, we do not recommend PEScience Prolific to our readers.

PEScience Prolific Review

PEScience Prolific is advertised as a powerful pre-workout supplement, that powers up your workouts and helps you get better results. It certainly includes some popular ingredients and may produce some results in the beginning, but you are not going to see any significant improvement in mind-muscle connection, endurance, or muscle gain. It may help a bit with recovery, but do not expect much in other areas.

Even the ingredients in PEScience Prolific do not have sufficient scientific evidence to support their use. For instance, it contains L-citrulline, which is actually a common ingredient found in pre-workout supplements. It helps improve muscle recovery by promoting better blood circulation. It also helps relax your blood vessels, which is the reason why it may prove beneficial for people suffering from hypertension, erectile dysfunction, or diabetes. In terms of muscle gain, it is not going to deliver a powerful punch.

Some supplement manufacturers say that citrulline can improve endurance for aerobic and anaerobic activities, but most studies do not support these claims. Some studies have observed positive results but only when very large doses were administered. For instance:

  • In an incline walking test until failure in otherwise healthy persons, 3g or 9g citrulline (acutely or over 24 hours, respectively) appeared to actually reduce time to exhaustion (0.8%, a clinically irrelevant degree) and suppressed the exercise-induced increase in insulin. Other biomarkers tested were unaltered, although heart rate trended to decrease with 3g citrulline.

PEScience Prolific Facts

  • 20 servings per container
  • Natural ingredients

Although PEScience Prolific provides you with a good dose of L-citrulline, you may have to take even more to see positive results. It is also thought that L-citrulline plays a role in Nitric Oxide synthesis, which in turn improves endurance and sports performance. Some studies are available to support this claim, but the effects are not that significant. For instance:

  • A double-blind randomized placebo-controlled 2-way crossover study was employed. Twenty-two trained males consumed 2.4 g/day of L-citrulline or placebo orally for 7 days. On Day 8 they took 2.4 g of L-citrulline or placebo 1 h before a 4-km cycling time trial. Time taken to complete the 4 km cycle, along with power output/VO2 ratio (PO/VO2), plasma nitrite and nitrate (NOx) and amino acid levels, and visual analog scale (VAS) scores, was evaluated. L-Citrulline supplementation significantly increased plasma L-arginine levels and reduced completion time by 1.5 % (p < 0.05) compared with placebo. Moreover, L-citrulline significantly improved subjective feelings of muscle fatigue and concentration immediately after exercise. Source

You also need to take large doses when you engage in strenuous workouts. For instance:

  • Supplementation with 8g citrulline (as malate, with 10g sugar that was also used in placebo condition) during a weight lifting protocol (perform as many reps as possible until fatigue for multiple sets) noted that citrulline was able to delay fatigue and promote more reps performed per set for all sets, except the first two and reduced post-workout muscle soreness. Source

PEScience Prolific offers a good dose of L-citrulline, but it is certainly not enough. Another issue is that not everyone can tolerate high doses of L-citrulline, which is why many people may end up experience some side effects as well.

Each serving of PEScience Prolific provides you with 1,500mg of taurine, which is again a good dose, but you may or may not experience any benefit because of taurine supplementation. It is supposed to increase testosterone levels and athletic performance. Some supplement manufacturers believe that taurine also helps treat ADHD symptoms. Unfortunately, more research is required to confirm the claims associated with taurine supplementation. Many studies have shown contradictory results, which is another issue associated with its use. For instance:

  • “One study conducted with cyclists found that 1 gram of taurine taken 2 hours prior to exercise improved performance on a 3-kilometer time trial by 1.7%. Another study, however, found that 1,660 mg of taurine taken an hour before cycling failed to improve time trial performance.”

Some animal studies have noticed positive results, but those studies used more than 2,000mg of taurine a day. An issue with taurine use is that it can cause brain damage when very high doses are administered. Therefore, it is better to avoid it in the first place.

How to Take PEScience Prolific

You have to take 2 scoops before your workout to experience its benefits. There are 20 servings per container.

PEScience Prolific contains caffeine that stimulants your central nervous system and claims to reduce fat and improve mental alertness. Again, not all studies have noticed positive results of caffeine supplementation. Some studies have failed to notice any change in performance and endurance after caffeine intake. Other studies have observed insignificant change in endurance. For instance:

  • Caffeine at doses of 3 mg/kg bw (equivalent to 210 mg for a 70-kg adult) ingested about one hour prior to endurance exercise appear to induce only a modest increase in body temperature compared to placebo. The Panel also notes that higher doses of caffeine (6 mg/kg bw 1569 equivalent to 420 mg for a 70-kg adult) ingested about one hour prior to prolonged endurance exercise in a hot environment do not affect body temperature or hydration status beyond what could be expected from the testing conditions.

Some experts believe that caffeine can help promote recovery and reduce muscle soreness, but scientific studies do not support these claims.

  • Muscle soreness during exercise. Evidence on the effect of caffeine for muscle soreness during exercise is inconsistent. It seems that taking moderate doses of caffeine (10 mg/kg) can reduce muscle pain during exercise, while lower doses may not have this effect.

While caffeine certainly stimulates your nervous system, it does not mean it can improve cognition or help treat depression symptoms. For instance:

  • Some research suggests that caffeine intake is linked with an increased occurrence of depression symptoms in children. However, other research suggests that caffeinated coffee intake is linked to a decreased occurrence of depression in adults.

Most people experience some results when they do not already have enough caffeine in their diet. However, the stimulating effects will start to wear away after some time, as your body gets used to the dose you are taking. You may have to increase the dose to get the same kick, but it may produce several side effects as well. You may even become so dependent on caffeine that it becomes difficult to stop taking it. You may even have to deal with withdrawal symptoms, such as decreased alertness, headache, tiredness, irritability, and depression. You should also bear in mind that caffeine works as a diuretic, which means that you may lose water and have a fluid imbalance.

  • Some research has shown that caffeine intake can also affect our fluid balance. In one study, 12 caffeine consumers were told to abstain from caffeine for five days and were then given 642 mg of caffeine in the form of coffee. Their urine output increased when given the caffeine.

You may even become dehydrated by taking higher doses of caffeine, and it can affect you in more ways than you can imagine. Therefore, it is a good idea to avoid supplementing with caffeine just to have a small improvement in stamina and endurance. Citicoline is also supposed to improve focus, energy and concentration, and some studies do support its use. For instance:

  • One 2012 research study from Food and Nutrition Sciences, working with healthy adult women aged 40-60 showed that after 28 days of citicoline supplementation the women had 600% fewer mistakes than the placebo group!

However, you need to take very high doses of citicoline, which you are not going to get from PEScience Prolific. Similarly, L-Theanine is not going to make a huge difference in your performance. In fact, it is usually included in a blend to prevent the side effects associated with a high caffeine intake. Do not expect much if you are already dealing with anxiety or depression symptoms. For instance:

  • In a 2011 study, researchers sought to determine L-theanine’s effect on attention and reaction time. The study concluded that participants experienced better attention and reaction time, but that “no significant differences were noticed among subjects with a minimal anxiety propensity.

It is worth mentioning that some experts believe that L-Theanine can improve serotonin levels and promote better mood, but other studies show that supplementing with L-Theanine may have a negative effect on serotonin levels and promote stress and tension. It is due to these contradictory results that you should avoid it as well.

PEScience Prolific Concerns:

  • Ineffective and under-dosed ingredients
  • Lack of scientific evidence
  • High in stimulants
  • Possible side effects
  • No money-back guarantee
  • Quite expensive

Rhodiola rosea is another ingredient found in PEScience Prolific, but you are not going to experience any benefits from this ingredient if you are an advanced lifter and have already tried some pre-workout supplements in the past. It is not that potent and you get no more than 100mg of rhodiola rosea from each serving of PEScience Prolific. Some studies suggest that it may reduce fatigue to a certain extent, but does nothing to reduce stress. For instance:

  • 144mg rhodiola (SHR-5) with 2.3% salidroside was able to reduce fatigue, but not stressed, in a cohort of otherwise healthy persons after 1 week of supplementation. Source

Some studies show that it improves mental alertness, but that happens when you take up to 170mg of rhodiola, which is not available in PEScience Prolific.

  • “In a double-blind study, supplementation with an extract of Rhodiola (1 tablet per day, providing 170 mg of extract and 4.5 mg of salidroside) for two weeks significantly improved mental fatigue in a group of physicians during night duty.”

Similarly, studies have failed to find any positive effect of rhodiola supplementation on reaction time. For instance:

  • In healthy and otherwise active (but not trained) individuals given an acute dose of 100mg rhodiola (3% rosavins and 1% salidroside) or 4 weeks of supplementation noted an improvement in time to exhaustion and VO2 max with no significant influence on power output. Attention and reaction time were unaffected in this study. Source

The fact of the matter is that PEScience Prolific contains several ingredients, but most of them are either under-dosed or lack enough scientific evidence to support their use. You may even have to deal with several side effects because of stimulants. When you consider all these drawbacks, it becomes obvious that the supplement is not worth your attention. Avoid it and look for something with scientifically proven ingredients and positive customer reviews. PEScience Prolific is not going to help!

What Does PEScience Prolific Claim To Do?

PEScience Prolific is a pre-workout supplement, and claims to help you in a number of ways. For instance:

  • Improves endurance and stamina
  • Reduces muscle soreness
  • Increases recovery
  • Reduces mental fatigue
  • Improves concentration and mood
  • Promotes fat loss and muscle gain

Does PEScience Prolific Work?

PEScience Prolific is essentially a pre-workout supplement geared towards advanced lifters. It contains ingredients that are supposed to help you complete your strenuous workout sessions with maximum intensity. Unfortunately, scientific studies do not support the formula used in PEScience Prolific. It contains L-citrulline – and certainly provides you with a reasonably high dose – but you may require more to see results. However, you just cannot afford to take very large doses because L-citrulline can cause several side effects as well. Taurine is also available in the blend, but it has produced contradictory results in many studies. It can even cause brain damage, which is why you should avoid it too. Caffeine in PEScience Prolific may improve endurance to a certain extent, but the effects are not going to be significant. Things are quite the same with other ingredients, which is the reason why we believe that you should avoid putting your money on this pre-workout supplement and try something else.

What Are The Ingredients of PEScience Prolific?

PEScience Prolific contains quite a few ingredients, but most of them do not have enough scientific evidence to support their use. Many of its ingredients are under-dosed, which is another reason why it is not going to prove effective. Here is what you will find in PEScience Prolific:

  • L-Citrulline 6,000mg
  • Betaine Anhydrous 2,500mg
  • Taurine 1,500mg
  • Caffeine [as caffeine anhydrous and dicaffeine malate (infinenergy™)] 320mg
  • Citicoline (Cognizin®) 250mg
  • L-Theanine 200mg
  • Rhodiola Rosea (root) Extract (5% Rosavins, 2% Salidroside) 100mg
  • Coffee Fruit Extract (NeuroFactorTM) 100mg

Does PEScience Prolific Have Any Side Effects?

PEScience Prolific includes different ingredients that can cause gastrointestinal side effects. You may experience nausea, vomiting, and abdominal pain after taking the supplement. Diarrhea is a common issue associated with supplements that contain L-citrulline. Taurine may also cause abdominal discomfort, and higher doses may result in brain damage. It can also affect your cardiovascular and immune system in a negative way.

The presence of caffeine is the reason why many customers complain about feeling restless. You may also experience other side effects, such as irritability, depression, increased heart rate, insomnia, and stomach irritation. Some problems like blurred vision, nausea, chest pains, and headaches could be the result of citicoline.

Are There Any Customer Reviews For PEScience Prolific?

PEScience Prolific claims to improve athletic performance and promote muscle gain, but it seems that most customers are not very happy with the results they receive. For instance:

I have been taking this supplement for three weeks now but it has done nothing to improve recovery time or muscle gain. It certainly does nothing to improve mind-muscle connection. It is a waste of your money.

I did experience some increase in endurance and stamina, but it was difficult to continue using it because of many side effects. I started feeling very restless and had a headache all the time. Avoid it if you cannot tolerate stimulants.

Does PEScience Prolific Offer a Money-Back Guarantee?

PEScience Prolific does not offer any money-back guarantee if you have already opened the container.

Where Can I Buy PEScience Prolific?

PEScience Prolific is available on its official website, but you can also buy it through some third-party retailers.

Summary: PEScience Prolific


PEScience Prolific

1.1 out of 5
PEScience Prolific Rating

The Muscle Watchdog does not recommend PEScience Prolific.

  • Effectiveness
  • Safety
  • Price / Guarantee

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Disclaimer: Our reviews and investigations are based on extensive research from the information publicly available to us and consumers at the time of first publishing the post. Information is based on our personal opinion and whilst we endeavour to ensure information is up-to-date, manufacturers do from time to time change their products and future research may disagree with our findings. If you feel any of the information is inaccurate, please contact us and we will review the information provided.

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