There are many people who find taking capsules inconvenient or even difficult, which has led the diet pills market to expand, providing weight loss ingredients in other forms. Alphamine, from PEScience, is a “powerful thermogenic powder” that comes in a variety of flavours and is mixed with water to make a tasty drink.

We take a look to see just how effective Alphamine really is below.

Alphamine Pros

  • Majority of reviews are positive

Alphamine Cons

  • Ingredients are under-researched
  • Long list of side effects
  • No money back guarantee from the manufacturer
Watchdog Rejected Muscle Pills

What You Need To Know About Alphamine

Whilst Alphamine does seem to be a promising product for those who are exercising regularly who want to increase their muscle mass and lose fat, we still do not know enough about the individual ingredients to approve this product.

The lack of human clinical trials means that we cannot state just how effective or safe any of the ingredients are. The proprietary formula also makes it difficult to establish just how strong this product is, as the ingredients could be present in any quantities- making it potentially too strong and more likely to cause side effects, or not strong enough to aid weight loss significantly.

What Are The Side Effects Of Alphamine?

What we do know about the ingredients is that some of them can cause a wide range of side effects, and that at least two of them, caffeine and yohimbe, can interact, making them more potent than when used separately. Certainly, the long caution list provided by the company should show that this product is most definitely not suited to everyone.

How Much Does Alphamine Cost?

Customers who do want to purchase this product should look for retailers other than the manufacturer, who sell the product at a much higher price than other stores, and offer no money back guarantee, along with charging a restocking fee on returns. Much better deals are available at other, reputable stores.

Our Verdict On Alphamine

Perhaps over the next few years more relevant clinical trials will be released, making it possible to more firmly establish just how effective and safe this diet supplement really is. Until then, it is not possible to approve Alphamine.

Alphamine Review

Alphamine Facts

  • Manufactured by PEScience
  • 84 servings- 4 week supply
  • Thermogenic powder

Alphamine is manufactured by PEScience, who are also known as Physique Enhancing Science. An American company, they offer a variety of products aimed at athletes and those who want to improve their physique.

How to Take Alphamine

Begin drinking 1 scoop mixed with 4-5 oz water on an empty stomach, 15-30 minutes before breakfast for the first two (2) days to assess tolerance.

An additional 1 scoop may be taken 5-6 hours later.

Once the above steps have been taken, an additional scoop may be added to the morning serving on day 3.


Consume at least 124 Fl. Oz. of liquid per day for men and 91 Fl. Oz. of liquid per day for women while taking this product.

Under no circumstances should the initial dose be exceeded or the warnings on the bottle be ignored.

The company can be contacted in a number of ways, including a generic contact form on their official website.

The company also have a huge online presence, with twitter, facebook and instagram accounts being added to regularly. Customers can also phone 888-885-0195, with the customer service hours being listed as 9am -12pm and 1pm – 4pm Eastern Standard Time.

Alphamine Concerns:

  • Under-researched ingredients
  • Long list of side effects
  • Some ingredients have unknown safety levels

What Does Alphamine Claim To Do?

According to the manufacturer:

This powerful thermogenic powder is designed to give a quick custom serving for every user. As a powdered product, each and every user can fully customize their serving size and frequency however they choose. No more being stuck with only 1 or 2 capsules… enjoy fully customizable servings anytime, anywhere. Everyone has different tolerances or “happy zones” for stimulant-based products…find YOUR sweet spot.

Alphamine mixes quick and easy with a spoon and tastes like something you’d only drink on your cheat days…no medicine mouth here! Two small scoops with 8-10 oz. of water and you can be on your way…

Whilst the company spends a lot of time promoting just how customisable their product is, they also note (more importantly) that it has the following benefits:

  • Extreme Thermogenic
  • Powerful Stimulants
  • Engineered Extracts
  • Thermogenic Igniting Technology

So What Does All This Mean?

Whilst quite a few of these ingredients are still under-researched in humans, overall they are promising. With a few stimulants that increase the metabolism, including caffeine, and Eucommia Ulmoides Leaf, which appears to help to decrease fat mass.

There are also numerous ingredients that could benefit athletes and regular gym-goers, through helping to build lean muscle mass, and by reducing muscle soreness and fatigue after physical activity.

So Does Alphamine Work?

Whilst the research on many of the ingredients is still preliminary, it is promising research. Whilst we need more information, especially in the form of human studies rather than experiments on rats, it could be that this thermogenic powder does aid weight loss, primarily in those who are exercising regularly, with the aim of increasing muscle mass as well as reducing fat mass.

The customer reviews indicate that this is certainly the case, with the majority of consumers reporting decreased appetite, increased speed of weight loss, a perceptible boost in energy, and increased sweating, indicating an increased metabolism. A few mention unpleasant side effects or a lack of weight loss results. This diet supplement does not seem to be suitable for those who do not wish to undertake regular exercise in the form of both cardio and weight training.

So What Is Alphamine and What Are The Ingredients for Alphamine?

The active ingredients used in Alphamine are listed below. The formula is proprietary, and so the company does not have to release the individual ingredient quantities used in the product. However, the company has stated that each 3 gram scoop contains 1577.5 mg of the Alphamine FIT matrix, which includes 125 mg of caffeine anhydrous.

Serving Size : 1 Scoop (3 g)
Servings Per Container: 84

Alphamine FIT Matrix (1,577.5mg) – Lean Performance System

  • Choline Bitartrate: Athletes use this when bodybuilding and for delaying fatigue.
  • Alpha-Hydroxy-Isocaproic Acid: A currently under-researched ingredient, there is currently a single study that shows its use leads to increased gains in lean muscle mass in training athletes. There appears to be no effect upon fat mass at all.
  • Eucommia Ulmoides Leaf (98% Chlorgenic Acid): Preliminary evidence suggests that Eucommia Ulmoides Leaf could play a role in reducing fat mass, although there is a lack of evidence from studies in humans at this time. It also helps to regulate insulin sensitivity.
  • Olive Leaf Extract: Olive Leaf Extract is used for treating infections and viruses such as the common cold. It is also used to treat chronic fatigue; if this is effective, it could help athletic endurance. Studies also show that the consumption of olive leaf extracts, even in small quantities, reduces LDL Cholesterol levels, and can lower blood pressure. Also appears to boost the production of thyroid hormones, which should indirectly boost the metabolism. However, the resultant weight loss results were minimal or non-existent, suggesting that its metabolic boosting effects are fairly insignificant.

Ergo-Thermogenic System

  • Caffeine Anhydrous (125mg): Numerous studies have shown that caffeine boosts energy levels and alertness, as well as mildly boosting the metabolism, causing a small increase in the number of calories used by the body. The effects shown in studies are small, and some studies are inconclusive.
  • Higenamine HCl: This is chemical that acts as a stimulant. It is thought to work in a similar way to ephedrine and synephrine from bitter orange extract, but appears to be not as potent.
  • Pausinystalia Yohimbe (Bark) Extract (SA2-A): Some studies have noticed increased blood concentrations of free fatty acids in participants who use yohimbe extract, suggesting increased rates of lipolysis. However, the Natural Medicines Comprehensive Database has stated that there is insufficient evidence to claim it aids in weight loss.

Does Alphamine Have Any Side Effects?

Because there are limited studies into many of the ingredients, it is possible that not all of the possible side effects of these ingredients are documented– for example, Higenamine is largely under-researched, and could have side effects typically associated with stimulants such as increased heart rate, heart palpitations and increased sweating, although none of these have been confirmed.

Caffeine can cause headaches, increased blood pressure, increased heart rate, heart palpitations, increased urination, jitteriness, dehydration and insomnia.

Choline is likely safe in appropriate amounts, but as this is a proprietary formula and so the amounts used are unknown. Increased dose are more likely to cause side effects such as sweating, a fishy body odour, gastrointestinal distress, diarrhoea, and vomiting.

Yohimbe has been linked with irregular or rapid heartbeat, kidney failure, seizure, and heart attack in rare cases.

More common side effects include stomach upset, tremor, sleep problems, anxiety or agitation, high blood pressure, a racing heartbeat, dizziness, stomach problems, drooling, sinus pain, irritability, headache, frequent urination, bloating, rash, nausea, and vomiting. It may also interact with caffeine, increasing the chances of side effects.


Do not use if pregnant or nursing.

This product is only intended for healthy adults, 18 years of age or older.

Before using this product consult with your physician if you are using any prescription or over the counter medication or if you have or suspect you have any pre-existing medical condition including but not limited to: high or low blood pressure, cardiac arrhythmia, stroke, heart, liver, kidney or thyroid disease, seizure disorder, psychiatric disease, diabetes, difficulty urinating due to prostate enlargement or if you are taking a MAOI (Monoamine Oxidase Inhibitor) or any other medication.

Discontinue use and consult your health care professional if you experience any adverse reaction to this product.

Do not use if safety seal is broken or missing. Store in a cool dry place.

Keep out of reach of children.

Any Alphamine Reviews From Customers?

There are numerous reviews of Alphamine available from customers, as it is sold on a variety of online retail stores, including and Whilst many of the reviews are positive, there are a small but significant number of poor reviews from the product:

I must be Mr. Opposite. This stuff gave me a voracious appetite. The first week I used it – I gained 4 pounds. I stopped using it and my appetite returned to normal and I lost the 4 pounds. I tried again the week after and I took it in the morning, and sure enough – I was trying to eat everything in sight for the rest of the day. This may work for some, but others – beware, it may have an opposite effect.

This stuff makes me feel like what I imagine smoking a whole bunch of crack would make you feel like. Also I get hungry. Boo to this.

Some of the negative reviews on amazon mention numerous faulty products being delivered, with the quality seal being ripped and the product being affected. Customers who have experienced this recommend using a more professional distributer such as or the manufacturer themselves.

Despite the few negative reviews, the overall feedback on this positive is generally very good, with customers reporting significant appetite suppression and a significant energy boost, with no crash or jitters, as well as actually losing weight.

I really never review things on amazon. But, then I realized that many people only review if a product is bad to warn other people. So I thought I would reverse that trend and say that I used this product and loved it. I never got tired of the taste. Every morning I would drink it right before work. It would wake me up just fine. I never really had the jitters, but I also didn’t drink any coffee while on this. After a month of use and adjusting my diet I managed to go from 170 to 155ish. None of my max lifts went down, although they did not go up as quickly as when I am not cutting.
I would drink this in the morning, then about 1 hour later I would have a bowl of oatmeal with a scoop of chia seeds and that would keep me full well past lunch. Many times I had to force myself to eat.
Like any workout product, some things work for people and some don’t. This worked surprisingly good for me and that is why I am giving it 5 stars.

I lost about 15 pounds during an 8 week cycle on Alphamine and it continued to curb my appetite. I still take it because I like it better than coffee or anything else for energy. It says not to take for more than 8 weeks so I do cycle off every 8 weeks. I retained 50% more lean mass than I ever have in the past when losing weight. The weight has not come back in fact I kept losing, so I’ve lost more than the 15 but 15 is what I lost during the 8 week cycle. This is pretty much my favorite supplement and I’ve tried a ton. I’m gonna try one called “Amphetalean” purely to switch things up and because I heard it’s good. I don’t really have any negative side effects to report but did notice my sex drive increased on Alphamine, I’m guessing due to the yohimbe. I wouldn’t say that’s good or bad since it depends. I already had a healthy sex drive, but if you have a low sex drive then I guess that’s a plus.

What About A Guarantee

Customers purchasing direct from the manufacturer are not offered a money back guarantee, with no returns being available on open or used merchandise.

The company states:

All returns are subject to a 15% restocking fee (except for damaged goods). For the safety of our customers, bulk powders are not returnable for exchanges, credits, or refunds under any circumstance.

We recommend that, as the product is available much cheaper elsewhere, and other companies, such as, have much better returns policies, that customers shop around before purchasing this product. This may also work out better for international shoppers as well, as customers at the site need to pay either by credit card or PayPal in US Dollars.

Where Can I Buy Alphamine?

Alphamine can be purchased from a variety of online retailers. From the manufacture, a single tub costs $59.99. A single tub contains 84 servings, enough for a 28 day supply when using 3 scoops per day, the recommended maximum daily serving. has the same sized tub available for the highly discounted price of $32.98 plus delivery.

Whilst the UK store of does not offer the product, UK customers will be glad that other sites do carry the product: offer a single tub for £27.99, with free delivery, or offer two or more tubs for £25.99 each. offer a single tub for £23.95, and offer extra discounts for bulk purchases.

As prices are constantly changing, and this is not a definitive list of suppliers, it definitely works in the customer’s favour to shop around for the best deal, rather than simply purchasing direct from the manufacturer.

Summary: Alphamine

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1.8 out of 5
Editor's Rating
  • Effectiveness
  • Safety
  • Price / Guarantee

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Disclaimer: Our reviews and investigations are based on extensive research from the information publicly available to us and consumers at the time of first publishing the post. Information is based on our personal opinion and whilst we endeavour to ensure information is up-to-date, manufacturers do from time to time change their products and future research may disagree with our findings. If you feel any of the information is inaccurate, please contact us and we will review the information provided.

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